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no prescription alesse "The risk increases with the number of the first-degree relatives affected. Having a twin brother with gout carries an eight-fold risk, whereas having a parent or offspring with gout has a two-fold risk. The study also demonstrates that in addition to the genetic risk, shared environment factors play a substantial role in the aetiology of gout. The influences of environmental and genetic factors on the risk of gout are different in men and women. Genetic factors contribute one-third in men and one-fifth in women."